Journal Paper

Publication Types:

Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate

Journal Paper
Yiwen R. Chen, Itamar Harel, Param Priya Singh, Inbal Ziv, Eitan Moses, Uri Goshtchevsky, Ben E. Machado, Anne Brunet, Daniel F. Jarosz
Developmental Cell
Publication year: 2024

The killifish germline regulates longevity and somatic repair in a sex-specific manner

Journal Paper
Eitan Moses, Tehila Atlan, Xue Sun, Roman Franěk, Atif Siddiqui, Georgi K. Marinov, Sagiv Shifman, David M. Zucker, Adi Oron-Gottesman, William J. Greenleaf, Ehud Cohen, Oren Ram & Itamar Harel
Nature Aging
Publication year: 2024

Identification of protein aggregates in the aging vertebrate brain with prion-like and phase-separation properties

Journal Paper
Itamar Harel, Yiwen R. Chen, Inbal Ziv, Param Priya Singh, Daniel Heinzer, Paloma Navarro Negredo, Uri Goshtchevsky, Wei Wang, Gwendoline Astre, Eitan Moses, Andrew McKay, Ben E. Machado, Katja Hebestreit, Sifei Yin, Alejandro Sánchez Alvarado, Daniel F. Jarosz, Anne Brunet
Cell Reports
Publication year: 2024

Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate

Journal Paper
Gwendoline Astre, Tehila Atlan, Uri Goshtchevsky, Adi Oron-Gottesman, Margarita Smirnov, Kobi Shapira, Ariel Velan, Joris Deelen, Tomer Levy, Erez Y Levanon, Itamar Harel
Dev Cell . 2023 Aug 7;58(15):1350-1364.e10
Publication year: 2023

A scalable and tunable platform for functional interrogation of peptide hormones in fish

Journal Paper
Eitan Moses, Roman Franek, Itamar Harel
Elife 12, e85960
Publication year: 2023

CRISPR–Cas9 Genome Editing in Nothobranchius furzeri for Gene Knockout and Knock-In

Journal Paper
Itai Rozenberg, Eitan Moses, and Itamar Harel
Cold Spring Harb Protoc; doi:10.1101/pdb.prot107742
Publication year: 2022

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

Journal Paper
Benayoun BA, Pollina E, Singh PP, Mahmoudi S, Harel I, Casey K, Dulken B, Kundaje A, Brunet A
Publication year: 2018

Efficient genome engineering approaches for the short-lived African turquoise killifish

Journal Paper
Harel I, Valenzano DR, Brunet A
Nature Protoc. 11 (2016), pp. 20102028
Publication year: 2016

The African turquoise killifish genome provides insights into evolution and genetic architecture of lifespan

Journal Paper
Valenzano DR, Benayoun BA, Singh P, Zhang E, Etter PD, Hu CK, Clment-Ziza M, Willemsen D, Cui R, Harel I, Machado BE, Yee MC, Sharp SC, Bustamante CD, Beyer A, Johnson EA, Brunet A,
Cell 163 (2015), pp. 1539-1554
Publication year: 2015

Comprehensive transcriptome analysis using synthetic long-read sequencing reveals molecu- lar co-association of distant splicing events

Journal Paper
Tilgner H, Jahanbani F, Blauwkamp T, Moshre A, Jaeger E, Chen F, Harel I, Bustamante CD, Rasmussen M, and Snyder MP
Nature Biotechnol. 33 (2015), pp. 736742
Publication year: 2015

A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate

Journal Paper
Harel I, Benayoun BA, Machado B, Singh P, Hu CK, Pech MF, Valenzano DR, Zhang E, Sharp SC, Artandi SE, Brunet A
Cell 160 (2015), pp. 10131026
Publication year: 2015

 A Young Fish Comes of Age/ Cell Video Abstract [LINK]
 Research preview in Cell 160 (2015), pp. 814-815. [LINK]
 Research highlights in Nature Methods 12 (2015), pp. 289. [LINK]
 Recommended on Faculty of 1000. [LINK]

The actin regulator N-WASp is required for muscle-cell fusion in mice

Journal Paper
Gruenbaum-Cohen Y, Harel I, Umansky KB, Tzahor E, Snapper S, Shilo B, Schejter ED
PNAS 109 (2012), pp. 11211-11216
Publication year: 2012

Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis

Journal Paper
Harel I, Maezawa Y, Avraham R, Rinon A, Ma HY, Cross J, Leviatan N, Hegesh JT, Roy A, Jacob-Hirsch J, Rechavi G, Carvajal J, Tole S, Kioussi C, Quaggin S, and Eldad Tzahor
PNAS 109 (2012), pp. 18839- 18844
Publication year: 2012

The occipital lateral plate mesoderm - a novel source for vertebrate neck musculature

Journal Paper
Theis S, Patel K, Valasek P, Otto A, Qiu P, Harel I, Tzahor E, Tajbakhsh S, Christ B, and Huang R,
Development 137 (2010), pp. 2961-2971
Publication year: 2010

Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis

Journal Paper
Keymeulen AV, Mascre G, Youse KK, Harel I, Michaux C, De Geest N, Spalski C, Achouri Y, Bloch W, Hassan BA and Blanpain C,
JCB 187 (2009), pp. 91-100
Publication year: 2009

Distinct origins and genetic programs of head muscle satel- lite cells

Journal Paper
Harel I, Nathan E, Tirosh-Finkel L, Zigdon H, Guimar~aes-Camboa N, Evans SM, Tzahor E
Dev. Cell 16 (2009), pp. 822-832.
Publication year: 2009

 Research preview in Dev. Cell 16 (2009), pp. 779-780. [LINK]
 Recommended on Faculty of 1000. [LINK]

The contribution of Islet1-expressing splanch- nic mesoderm cells to distinct branchiomeric muscles reveals signif- icant heterogeneity in head muscle development

Journal Paper
Nathan E, Monovich A, Tirosh-Finkel L, Harrelson Z, Rousso T, Rinon A, Harel I, Evans SM, and Tzahor E,
Development 135 (2008), pp. 647-657
Publication year: 2008